Mathematics is useful for all , and a new research has emerged as a critical tool to increase the efficiency of a type of cancer treatments based on the use of certain viruses .
Researchers at the University of Ottawa in Canada, found suitable strategies using advanced mathematical models to fight cancer with the greatest possible efficiency.
Mathematics predict how different treatments and genetic modifications could allow oncolytic virus ( virus able to selectively kill cancer cells) overcome the natural defenses that cancer cells use to protect themselves from viral infections.
Oncolytic viruses are cited for their special ability to kill cancer cells without harming healthy .
Unfortunately , cancer is a very complicated and varied disease, so some of these viruses work well in some circumstances but not in others .
As a result , much effort has been invested in trying to modify the best possible way these viruses to make them safer , so that never harm healthy tissue while even more effective in killing cancer cells.
Team doctors John C. Bell and Mads Kaern , both from the Faculty of Medicine at the University of Ottawa, used mathematical modeling to develop strategies to make the cancer cells so vulnerable to infection of these viruses as possible , with this result so sought that these viruses efficiently exterminate cancer cells without affecting healthy cells.
By using these mathematical models to predict how each variation in these viruses would affect normal cells and in cancer is feasible , as these researchers have shown , to find "shortcuts" in various lines of research , helping the community to accelerate scientific research and discoveries.
Bell and Kaern established a mathematical model describing a cycle of infection, including how a virus replicates , the cellular defense mechanisms spreads and active.
From there , these scientists used their knowledge of the key physiological differences between normal and cancer cells to identify how the modification of the virus genome could counteract the antiviral defenses of cancer cells .
The model simulations were remarkably successful , showing the efficiency of viral modifications identified to eradicate cancer in a disease model in mice.
This promising line of research offers many new perspectives. Just have taken the first steps for her to work on a specific type of cancer cells.
Scientists now investigate other types of malignant tumor cells under the same basic approaches to accelerate progress to help refine by virus attack against cancer cells .